(CNN): There are 521 cases of the novel coronavirus in the United States, according to the state and local health agencies, governments and the US Centers for Disease Control and Prevention.

There are 49 cases of repatriated citizens, including three from Wuhan China, 46 from the Diamond Princess cruise ship and 21 on the Grand Princess cruise ship.

There are 451 cases in 33 states and the District of Columbia, bringing the total number of coronavirus cases to 521, according to CNN Health’s tally of US cases that are detected and tested in the United States through public health systems.

A total of 21 people have died from the coronavirus in the US.