TEHRAN, June 3 (Xinhua) -- Iran's Supreme leader Ayatollah Ali Khamenei said here Friday that United States is the "enemy" of Islamic revolution of Iran and should not be trusted.

"The experience from the nuclear talks has shown that the United States will not quit its destructive measures" against Iran,  Khamenei made the remarks in a ceremony held to commemorate the 27th death anniversary of the founder of the Islamic republic, Ayatollah Ruhollah Khomeini.

In the nuclear negotiations, Iran sat with the representatives of the P5+1 (namely Britain, China, France, Russia, the United States, and Germany) and even separately with United States to reach a common ground, he said, adding that however, "the United State backed out and did not implement its commitments."

Iran and the world powers reached a nuclear agreement on the former's disputed nuclear program in July last year, which was implemented in January to lift some western sanctions against Iran in return for significant restrictions on Iran's nuclear activities.

Iran has incessantly said that fear from the U.S. pressures have stopped the international companies as well as the monetary institutions to cooperate with Iran in the aftermath of the nuclear implementation, hence no gain for Iran from the deal.

"If any political trend trusts the United States, it will commit a grave mistake," Khamenei said on Friday.

"The United States is the enemy of Iranian Islamic revolution, and this is in the nature of the United States that requires enmity, since their interests are in contradiction with Iran," he said, followed by the slogans of applaud from the big crowd.

The Iranian supreme leader reiterated his insistence on relying the domestic potentials to improve the economy of the country, and criticized the views which call for Iran's integration with the global economy.

The ceremony to commemorate the 27th death anniversary of Iran' s late leader on Friday was held at Khomeini's mausoleum in southern Tehran with the attendance of Iranian high-ranking officials and foreign diplomats and guests.